Episodes

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Episode 598 with Matthew Coe!

March 19, 2026

Comedian Matthew Coe (@matthew_coe__) joins Jesse, Andy and Matt to talk about parents watching comedy, Matthew's show My Therapist Knows Your Name, Matthew's hypoplastic right heart syndrome, the closing of the foramen ovale, a Japanese study of falling cats, a robot handling potato chips, and an averted Moon asteroid close call.

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Episode 597 with Jackie Kashian!

March 5, 2026

Comedian Jackie Kashian (@jackiekashian) returns to the show to talk with Jesse and Matt about her new standup special Alter-Kashian, huge amounts of hydrogen inside the Earth's core, weird things yawning does in your brain and a possible universal vaccine. See Matt on tour in Seattle and Portland, and Andy on tour in Santa Barbara.

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Episode 596 with Forrest Shaw!

February 26, 2026

Comedian and former marine biologist Forrest Shaw (@forrestshaw) returns to the show to talk with Matt, Andy and Jesse about his new live show The Ocean Hates You, his addiction podcast I've Got A Problem, bonnethead sharks, the rise of online sports gambling, a Kalshi market about aliens, and the myth of alpha wolves.

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Episode 595 with Aisha Alfa!

February 16, 2026

Comedian Aisha Alfa (@aishaalfa) joins Jesse, Andy and Matt to talk about comedy in Winnipeg, Jesse's Megyn Kelly-loved Olympics tweet, the cult movie Phantom of the Paradise, Andy's family friend Olympic ice dancer, the German word for a living stork with an arrow in it, the penis injection Olympic ski jumping controversy, an amazing artificial lung feat, Jesse's artificial lung cat bed, Aisha's newsletter and Andy's upcoming ska shows.

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Episode 594 with David Huntsberger!

February 4, 2026

Comedian David Huntsberger returns to the show to talk with Matt, Jesse and Andy about his podcast Intercepts, his new platform The Endless Abyss, the lost art of sketch comedy albums, the world's worst redaction, Redactle, how dogs build their vocabularies like toddlers, Stella the talking dog, dumb dogs, breed stereotypes, Bad Will Hunting, the worst logo and name in education, longevity in meat-eaters and the foresight of The Machine Stops.

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Episode 593 with Diya Basrai!

January 30, 2026

Comedian/neuroscientist Diya Basrai (@diyabasrai) joins Jesse, Andy and Matt to talk about Moravec's Paradox, whether there's something meat-specific about intelligence, a less-pessimistic AI take, a tool-using cow, Diya's comedy special and his comedy/science live show Uncontrolled Variables.

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Episode 592 with Jon Stringer!

January 21, 2026

Comedian Jon Stringer (@jonjstringer) joins Andy, Jesse and Matt to talk about living in a converted rural Kansas church, the intricacies of comedy competitions and cruise ship comedy, dry ice PVC soupcan launchers, the oldest known use of poison arrows, retail blowguns and their misuse, vibe-coding a band manager, why you should stop using hydrogen peroxide on cuts, sword canes and pendulous doorknockers.

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Episode 591 with Imaan Hadchiti!

January 13, 2026

Comedian Imaan Hadchiti (@imaanfrankhadchiti) joins Jesse, Andy and Matt to talk about Rima syndrome, the movie Tiptoes, the passing of an art legend, sniffing farts to prevent Alzheimer's, what actually causes ice to be slippery, when physical aging really kicks in and making paralyzed rats walk again in a really creepy way.

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Episode 590 with Waen Shepherd!

January 3, 2026

Comedian/actor/writer/composer Waen Shepherd (@waenshep) joins Andy, Jesse and Matt to talk about the new album from his alter ego Gary Le Strange, the biology of elves, the best chocolate chip cookie recipe, a runaway supermassive black hole, a lemon-shaped exoplanet and the music of Gary Wilson.

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Episode 589 with Chris Duffy!

December 28, 2025

Comedian/host/author Chris Duffy (@chrisiduffy) returns to the show to talk with Jesse, Andy and Matt about his new book Humor Me: How Laughing More Can Make You Present, Creative, Connected, and Happy, his radio show/podcast You're The Expert, his TED podcast How To Be a Better Human, the unintentionally phallic Covid-era Terry Crews video Chris worked on with Matt and Andy, prescribing standup to improve mental health, training Swedish crows to pick up cigarette butts and a frozen worm revived after 46,000 years.

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Episode 588 with Buddy Fitzpatrick!

December 16, 2025

Comedian Buddy Fitzpatrick (@buddycomic) joins Andy, Matt and Jesse to talk about Batman's effect on subway chivalry, the rooms of Madonna Inn, ladyfingers, manmade fire from 350,000 years earlier than previously thought, monogamy across the animal kingdom and an insane chain of rabies transmission via organ transplantation.

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Episode 587 with Adam Burke!

December 8, 2025

Comedian Adam Burke (@atpburke) joins Andy, Jesse and Matt to talk about Adam's new comedy special Unamerican, debunking the Stanford Prison Experiment, classic '80s Arnold movies, Matt and Jesse performing together in Nashville, the preacher who shot an escaped lab monkey, AIs that believe themselves to be more rational than humans, 3D printing with a mosquito proboscis, Andy's upcoming orchestra shows and Matt's upcoming San Deigo standup show.

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Episode 586 with Ophira Eisenberg!

November 28, 2025

Comedian/writer/NPR host Ophira Eisenberg (@ophirae) joins Andy, Jesse and Matt to talk about her podcast Parenting Is a Joke, her upcoming special produced by Lewis Black, the effect of venting on anger, a rage room show Andy worked on, why you should leave uncontacted tribes alone, the wombat-thief influencer and why you should speak up to seagulls.

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Episode 585 with Jeff Zenisek!

November 14, 2025

Comedian Jess Zenisek (@jeffzenisek) joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona, Mr. Wizard, Jeff's hair care regimen, a tiny tyrannosaur, a better rock-paper-scissors strategy, gray hair's relationship to cancer, the worst music to play during sex and the banger Parked By The Lake.

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Episode 584 with Drew Droege!

November 9, 2025

Comedian/playwright Drew Droege (@drew_droege) joins Matt, Jesse and Andy to talk about his new off-Broadway play Messy White Gays, X-ray NBA poker fraud and why birds sing after a solar eclipse.

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Episode 583 with Mehran Khaghani!

October 29, 2025

Wonderful NY comic Mehran Khagani (@themehran) joins Jesse and Matt to talk about escaping from Iran, working at the Harvard School of Public Health, hyrax butt drag fossil marks, Canadian heart transplants and the most pristine star in the universe.

In the Patreon bonus ep we get into penguin micronaps.

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Episode 582 with Jen Kober!

October 20, 2025

Comedian/actor Jen Kober (@jenkober) joins Andy, Jesse and Matt to talk about comedy in Louisiana, Oktoberfest, buxom wenches, the connection between fish buttholes and fingers, a koala chlamydia vaccine, Jesse's newfound raccoon fame, light-powered gears that fit inside a strand of hair and Jen's membership in the Star Wars canon.

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Episode 581 with NASA Exoplanet Science Ambassador Anjali Tripathi!

October 5, 2025

NASA astrophysicist and JPL Exoplanet Science Ambassador Anjali Tripathi joins Andy, Jesse and Matt to talk about exoplanets and the different ways of finding them including radial velocity, transits and gravitational microlensing, the challenges of studying planetary atmospheres, why telescopes are built in deserts or in space, Anjali's time at the White House Office of Science and Technology Policy, science communication projects like the Logic 44ever rap video, the upcoming Nancy Grace Roman Space Telescope, dark matter, lasers in astronomy, Halloween at the White House, the odd “smells” of other planets and how to take a virtual tour of JPL.

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Episode 580 with Michelle Murphy!

September 27, 2025

Comedian Michelle Murphy (@meeshoffleash) joins Andy, Matt and Jesse to talk about playing tennis for Grinnell, the Enhanced Games, celebrities trying their hands at winter sports, Jesse's accidental mermaid book purchase and the Dr. Seuss book he was aiming for, Burning Man missionaries, LSD to fight anxiety and surprisingly not too uncommon iridescent mammals.