Professional comedians with so-so STEM pedigrees take you through this week in science. Incompetently. Featuring Matt Kirshen, Andy Wood, Jesse Case and guests.

Episodes

Episode 612 with Alison Leiby!

July 26, 2026

Comedian/writer Alison Leiby (@alisonleiby) joins Jesse, Andy and Matt to talk about her new memoir I'm A Lot, AI promotional scams, chronic back pain, how happiness can literally break your heart, takotsubo octopus traps, a breatkthrough in Alzheimer's-related sleep loss, plaque talk, inhaling CO2 to help with Alzheimer's, debunking the electric pangolin, giraffe math and ranking the intelligence of animals and demons.

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Episode 611 with Hannah Roeschlein!

July 16, 2026

Hannah Roeschlein (@handerpumprules) joins Jesse and Matt for half the episode before the computer gods get angry, forcing the two guys to finish the show solo. But between us we talk about Filipino divers, Synthetic cells And Hobbits and Komodo dragons.

In the Patreon bonus, we get into space fires, and hear how Matt got served by a legendary astronaut and Jesse angered BBQ fans.

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Episode 610 with Kirk Smith!

July 5, 2026

Comedian Kirk Smith (@kirksmithcomedy) joins Jesse, Andy and Matt to talk about his books Rice Krispies with Ketchup and Movin, pools and jacuzzis, competitive eating champions, the science of fireworks, the lack of rap in the Billboard Hot 100 and Andy's upcoming Oregon tour.

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Episode 609 with Ryan Conner!

June 26, 2026

Comedian/author Ryan Conner (@ryanconnercomedy) returns to the show to talk with Jesse, Andy and Matt about his new memoir 12 Guys Walk Into a Kitchen, Vietnamese refugees, Tippi Hedren's nail salon legacy, British soccer fans cleaning up in the US, the worst year to be alive, 2020 vs. 1968, hipster nostalgia, stomp clap tall bikes and nuclear (not atomic) clocks.

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Episode 608 with Laura Sams Jordan!

June 18, 2026

Zoologist/producer/composer/podcaster Laura Sams (@lauramsams) Jordan joins Jesse, Matt and Andy to talk about fliming grizzly bears in Alaska, studying hyenas in Africa, Laura's kid-friendly wildlife podcast The Happiest Animal Show, starting a production company with your sibling, interviewing six-year-olds, Laura's inflatable basking shark, the shocking actual appearance of basking sharks, the Horniman walrus, they're all in my Wildlife Treasury, a duck in a jersey and inserting a human language gene into mice.

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Episode 607 with Diana Hong!

June 3, 2026

Comedian Diana Hong (@dhongcomedy) joins Jesse, Andy and Matt to discuss cat ownership, Shadow Force, Sawbones and the McElroy-iverse, Diana's golf career, outsider commemorative art, a new way to get your lithium, battery types, alkali metals reacting with water, Lithium Valley, bottle recycling in the US, Sonny Bono's Palm Springs legacy, awful bronze statues, RIP Primm (maybe), an optimal robot body with 20 legs and Old Glory Robot Insurance.

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Episode 606 with Charles Star!

May 29, 2026

Lawyer-turned-comedian and self-professed podcast slut Charles Star (@ugarles) returns to the show to talk about his podcast No Homework, celebrity roasts, Wings album covers, bad abbreviations, contact lenses that ease depression in mice, the insect with the biggest nuts, self-recognition in beluga whales and the link between sleep duration and accelerated aging.

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Episode 605 with James Frey!

May 18, 2026

Comedian and former paramedic James Frey (@jamesfreycomedy) joins Andy, Jesse and Matt to talk about firefighter dreams and emergency medicine reality, James' Ventura comedy show, giving CPR in civilian life, a woman (well, women) who couldn't burp, getting fobbed off, sucker fish hiding in manta rays' butts, a quantum battery breakthrough and missing scientist conspiracy theories.

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Episode 604 with Shane Mauss!

May 11, 2026

Comedian Shane Mauss (@shane_mauss) returns to the show to talk about his upcoming comedy special TRIPS: The First Dose, how LSD affects blind people, misophonia's link to anxiety and depression, the goring of a matador's ass, plants 'hearing' rain coming and Shane's comedy/science podcast Here We Are.

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Episode 603 with Brandie Posey!

May 3, 2026

Comedian Brandie Posey (@brandazzle) returns to the show to talk with Jesse, Andy and Matt about the geography of Jersey, Brandie's label Burn This Records and her new comedy special Milk Job, Andy's other ska band, why humans can't regenerate limbs, a huge volcano refilling with magma, the dude who got both his arms reattached in 1992, whether Yellowstone is due for an eruption and Fruit Love Island.

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Episode 602 with Chandler Dean!

April 24, 2026

Comedian/speechwriter Chandler Dean (@chandlerjdean) joins Jesse, Andy and Matt to talk about his show Abolish Everything!, Jesse's over-the-top stuffed animal purchase, poop speed as a health indicator, the Bristol Stool Chart, medical fake poo, Jesse's obsessions with fake foods, giant stuff and really tiny stuff, Artemis II's avatar crewmates, the magic of Tiny Empath Babies, videos of Tiny Empath Babies and more videos of Tiny Empath Babies.

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Episode 601 with Amber Preston!

April 17, 2026

Comedian Amber Preston (@prestonparty) returns to help Andy, Jesse and Matt celebrate the big six-oh-one and talk about Artemis II, frozen urine in space, a microbe that makes you stronger, Trump's insane handshakes, sharks testing positive for cocaine and sperm difficulties in zero-g.

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Episode 600 with Katie Novotny!

April 6, 2026

Comedian Katie Novotny (@katienovotnyyyyy) joins Matt and Andy to discuss her special Son of Your Dreams, whale junk, headbutting whales, the 20-year cycle of fashion, an evolved arsenic tolerance, Thai children who can see underwater and a Warsaw Poland Bros. song Andy plays on.

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Episode 599 with Monica Nevi!

March 29, 2026

Comedian Monica Nevi (@monicanevi) joins Andy, Jesse and Matt to talk about her special Big Stepdad Energy, what VO2 max means, esports scholarships, vasectomy rate spikes during March Madness, the effect of carbonated water on gamer performance, a bunch of human brain cells in a petri dish playing Doom, unlocking the antibacterial secrets of frogs and using frogs to keep milk from spoiling.

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Episode 598 with Matthew Coe!

March 19, 2026

Comedian Matthew Coe (@matthew_coe__) joins Jesse, Andy and Matt to talk about parents watching comedy, Matthew's show My Therapist Knows Your Name, Matthew's hypoplastic right heart syndrome, the closing of the foramen ovale, a Japanese study of falling cats, a robot handling potato chips, and an averted Moon asteroid close call.

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Episode 597 with Jackie Kashian!

March 5, 2026

Comedian Jackie Kashian (@jackiekashian) returns to the show to talk with Jesse and Matt about her new standup special Alter-Kashian, huge amounts of hydrogen inside the Earth's core, weird things yawning does in your brain and a possible universal vaccine. See Matt on tour in Seattle and Portland, and Andy on tour in Santa Barbara.

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Episode 596 with Forrest Shaw!

February 26, 2026

Comedian and former marine biologist Forrest Shaw (@forrestshaw) returns to the show to talk with Matt, Andy and Jesse about his new live show The Ocean Hates You, his addiction podcast I've Got A Problem, bonnethead sharks, the rise of online sports gambling, a Kalshi market about aliens, and the myth of alpha wolves.

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Episode 595 with Aisha Alfa!

February 16, 2026

Comedian Aisha Alfa (@aishaalfa) joins Jesse, Andy and Matt to talk about comedy in Winnipeg, Jesse's Megyn Kelly-loved Olympics tweet, the cult movie Phantom of the Paradise, Andy's family friend Olympic ice dancer, the German word for a living stork with an arrow in it, the penis injection Olympic ski jumping controversy, an amazing artificial lung feat, Jesse's artificial lung cat bed, Aisha's newsletter and Andy's upcoming ska shows.

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Episode 594 with David Huntsberger!

February 4, 2026

Comedian David Huntsberger returns to the show to talk with Matt, Jesse and Andy about his podcast Intercepts, his new platform The Endless Abyss, the lost art of sketch comedy albums, the world's worst redaction, Redactle, how dogs build their vocabularies like toddlers, Stella the talking dog, dumb dogs, breed stereotypes, Bad Will Hunting, the worst logo and name in education, longevity in meat-eaters and the foresight of The Machine Stops.

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Episode 593 with Diya Basrai!

January 30, 2026

Comedian/neuroscientist Diya Basrai (@diyabasrai) joins Jesse, Andy and Matt to talk about Moravec's Paradox, whether there's something meat-specific about intelligence, a less-pessimistic AI take, a tool-using cow, Diya's comedy special and his comedy/science live show Uncontrolled Variables.

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